The 31st Annual Meeting of the International Society for Traumatic Stress Studies (ISTSS), November 5–7, 2015, was a vibrant and stimulating conference, with many highlights from the opening on the 10th anniversary of Hurricane Katrina; the keynotes of Anke Ehlers, John Krystal, and Regina Sullivan; the vivid panel discussions with recognized leaders in the field of traumatic stress studies; inspiring and eloquent presentations by master methodologists and clinicians; and much more.