Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults : results from the PGC-ENIGMA PTSD consortium

A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3047 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1426 individuals with PTSD and 1621 controls (2174 males/873 females) between ages 18–83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen’s d = −0.11, p = 0.0055). The tapetum connects the left and right hippocampus, for which structure and function have been consistently implicated in PTSD. Results were consistent even after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network.

 



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Reference: 
Emily L Dennis PhD, Seth G Disner PhD, Negar Fani PhD, Lauren E Salminen PhD, Mark Logue PhD, Emily K Clarke MSc, Courtney C Haswell PhD, Christopher L Averill BSc, Lee A Baugh PhD, Jessica Bomyea PhD, Steven E Bruce PhD, Jiook Cha PhD, Kyle Choi MPH, Nicholas D Davenport PhD, Maria Densmore BSc, Stefan du Plessis PhD, Gina L Forster PhD, Jessie L Frijling PhD, Atilla Gönenc PhD, Staci Gruber PhD, Daniel W Grupe PhD, Jeffrey P Guenette MD, Jasmeet Hayes PhD, David Hofmann MSc, Jonathan Ipser PhD, Tanja Jovanovic PhD, Sinead Kelly PhD, Mitzy Kennis PhD, Philipp Kinzel BSc, Saskia BJ Koch PhD, Inga Koerte MD,PhD, Sheri Koopowitz MSocSc, Mayuresh Korgaonkar PhD, John Krystal MD, Lauren AM Lebois PhD, Gen Li PhD, Vincent A Magnotta PhD, Antje Manthey BSc, Geoffrey J May MD, Deleene S, Menefee PhD, Laura Nawijn PhD, Steven M Nelson PhD, Richard WJ Neufeld PhD, Jack B Nitschke PhD, Daniel O'Doherty BSc, Matthew Peverill BA, Kerry Ressler MD,PhD, Annerine Roos PhD, Margaret A Sheridan PhD, Anika Sierk PhD, Alan Simmons PhD, Raluca M Simons PhD, Jeffrey S Simons PhD, Jennifer Stevens PhD, Benjamin Suarez-Jimenez PhD, Danielle R Sullivan PhD, Jean Théberge PhD, Jana K Tran PhD, Leigh van den Heuvel MD, Steven JA van der Werff PhD, Sanne JH van Rooij PhD, Mirjam van Zuiden PhD, Carmen Velez MSc, Mieke Verfaellie PhD, Robert RJM Vermeiren MD,PhD, Benjamin SC Wade PhD, Tor Wager PhD, Henrik Walter MD,PhD, Sherry Winternitz MD, Jonathan Wolff BSc, Gerald York MD, Ye Zhu PhD, Xi Zhu PhD, Chadi G Abdallah MD, Richard Bryant PhD, Judith K Daniels PhD, Richard J Davidson PhD, Kelene A Fercho PhD, Carol Franz PhD, Elbert Geuze PhD, Evan M Gordon PhD, Milissa L Kaufman MD,PhD, William Kremen PhD, Jim Lagopoulos PhD, Ruth A Lanius PhD, Michael J Lyons PhD, Stephen R McCauley PhD, Regina McGlinchey PhD, Katie A McLaughlin PhD, William Milberg PhD, Yuval Neria PhD, Miranda Olff MD,PhD, Soraya Seedat PhD, Martha Shenton PhD, Scott R Sponheim PhD, Dan J Stein PhD, Murray B Stein MD, Thomas Straube PhD, David F Tate PhD, Nic JA van der Wee MD,PhD, Dick J Veltman MD, MD,PhD, Li Wang PhD, Elisabeth A Wilde PhD, Paul M Thompson PhD, Peter Kochunov PhD, Neda Jahanshad PhD, Rajendra A Morey MD | 2019
In: Molecular Psychaitry ISSN: 1476-5578 (online) | december
https://doi.org/10.1038/s41380-019-0631-x
Online verschenen 19/12/2019
Keywords: 
Alcohol Abuse, Comorbidity, Complex PTSD, Depressive Symptoms, Injuries, Posttraumatic Stress Disorder, Psychotrauma, PTSD (en), Research
Affiliation author(s): 
ARQ Centrum’45 (en), ARQ National Psychotrauma Centre