ARQ Centrum’45 (en)

English

Severity profiles of posttraumatic stress, depression, anxiety, and somatization symptoms in treatment seeking traumatized refugees

Background: Western countries are facing many challenges hosting refugees from several regions in the world. Many of them are severely traumatized and suffer from a variety of mental health symptoms, which complicates the identification and treatment of refugees at risk. This study examined subgroups based on a broad range of psychopathology, and several predictors, including trauma characteristics and gender. 

Pharmacological Prevention of PTSD: Current Evidence for Clinical Practice

Posttraumatic stress disorder (PTSD) is a disabling psychiatric disorder that develops in approximately 10% of people exposed to trauma. As traumatic events are the point of reference for PTSD symptom onset, the first hours to weeks posttrauma provide opportunities for preventive interventions. In this article, we discuss current evidence on pharmacological preventive interventions for PTSD in adults. We conclude that there are no pharmacological preventive interventions that are ready for routine clinical practice.

Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder

Background: Epigenetic mechanisms have been suggested to play a role in the development of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data (HumanMethylation450 BeadChip) collected prior to and following combat exposure in three cohorts of male military members were analyzed to assess whether DNA methylation profiles are associated with the development of PTSD. A total of 123 PTSD cases and 143 traumaexposed controls were included in the analyses.

Comparison of six proposed diagnostic criteria sets for disturbed grief

Increased recognition that grief may turn into a disorder led to the inclusion of Persistent Complex Bereavement Disorder (PCBD) in DSM-5 and Prolonged Grief Disorder (PGD) in ICD-11. Four additional criteria sets for disturbed grief have been proposed in recent years: Prigerson et al. proposed criteria for PGD (“PGD-2009″), Maercker et al. presented an ICD-11 beta draft version of PGD (“PGD-BD”), Shear et al. put forth criteria for complicated grief (“CG”), and, recently, criteria for PGD in DSM-5-TR have been proposed.

The prevalence of prolonged grief disorder in bereaved individuals following unnatural losses: Systematic review and meta regression analysis

Background: Previous research has indicated that one out of ten naturally bereaved individuals develops prolonged grief disorder (PGD). Less is known about the prevalence of PGD following unnatural deaths, such as accidents, disasters, suicides, or homicides. The aim of this study was to compute the pooled prevalence of PGD and to determine possible causes of its varied estimates.

Severity profiles of posttraumatic stress, depression, anxiety, and somatization symptoms in treatment seeking traumatized refugees

Background: Western countries are facing many challenges hosting refugees from several regions in the world. Many of them are severely traumatized and suffer from a variety of mental health symptoms, which complicates the identification and treatment of refugees at risk. This study examined subgroups based on a broad range of psychopathology, and several predictors, including trauma characteristics and gender.

Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults : results from the PGC-ENIGMA PTSD consortium

A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed, which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD.

Effectiveness of trauma-focused treatment for adolescents with major depressive disorder

Background: Major Depressive Disorder (MDD) in adolescence has a high prevalence and risk of disability, but current treatments show limited effectiveness and high drop-out and relapse rates. Although the role of distressing experiences that relate to the development and maintenance of MDD has been recognized for decades, the efficacy of a trauma-focused treatment approach for MDD has hardly been studied.

Facilitating grief : An exploration of the function of funerals and rituals in relation to grief reactions

The loss of a loved one through death is usually followed by a funeral and engagement in various grief rituals. We examined the association between the evaluation of the  uneral, the use of grief rituals and grief reactions. Bereaved individuals from the Netherlands completed questionnaires, six months and three years post-loss (n=552/289).

The spectral fingerprint of sleep problems in posttraumatic stress disorder

Study Objectives: Sleep problems are a core feature of post-traumatic stress disorder (PTSD). The aim of this study was to find a robust objective measure for the
sleep disturbance in patients having PTSD.
Methods: The current study assessed EEG power across a wide frequency range and multiple scalp locations, in matched trauma-exposed individuals with and
without PTSD, during rapid eye movement (REM) and non-REM (NREM) sleep. In addition, a full polysomnographical evaluation was performed, including sleep

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