Equator Foundation

Major Depressive Disorder (MDD) is a highly recurrent disease. Stress-responsive system dysfunction seems to persist after remission. In patients with more chronic and recurrent depressive episodes, state related HPA-axis dysregulation might be a risk factor for prospective recurrence. This study examines the predictive effect of cortisol on consecutive episodes in remitted recurrently depressed...

Trafficking in human beings (THB) has been described as modern slavery. It is a serious criminal activity that has significant ramifications for the human rights of the victims. It poses major challenges to the state, society and individual victims. THB is not a static given but a constantly changing concept depending on societal changes and opinions, economic situations and legal developments. THB occurs both transnationally and within countries. The complexity of THB is such that it requires a wide range of expertise fully to address the phenomenon.

The first studies on migration and mental health focused primarily on immigration in the Unites States in the beginning of the 20th century. Higher levels of mental health problems or “insanity” were observed among migrants as compared to host populations. Selective migration of mentally ill people was understood to explain this difference. Although hypomanic traits such as impulsiveness, extraversion and risk seeking behaviour may seem to predispose individuals to emigrate, the so-called selective migration hypothesis has never been empirically supported.

AbstractThis meta-analysis reviewed existing data on the impact of work-related critical incidents in hospital-based health care professionals. Work-related critical incidents may induce post-traumatic stress symptoms or even post-traumatic stress disorder (PTSD), anxiety, and depression and may negatively affect health care practitioners’ behaviors toward patients. Nurses and doctors often cope by working part time or switching jobs. Hospital administrators and health care practitioners themselves may underestimate the effects of work-related critical incidents.

The primary focus of this dissertation was to increase the knowledge about possible biological factors and psychopathological mechanisms (including HPA-axis functioning, one-carbon and fatty-acid metabolism), as well as some gene-environment interactions for the course of recurrent MDD (MDD-R). Studying MDD-R is important because there are indications that it represents a more biological and genetic determined MDD-subtype, which may be specifically linked to recurrence and CVD-risk.

Psychiatric illnesses are under polygenic influence and are associated with interactions between genetic variants and environmental exposures.1 Gene–environment interactions might not only predict onset of disease, but genetic biomarkers might also help the clinician to select the optimal treatment for patients.2 However, there is a lack of studies on therapygenetics for psychological treatment of psychiatric diseases.

Both depression and obesity share similar risk factors and are mutually associated. Amongobese people, depression is one of the most common psychiatric disorders 1. Studies inpersons seeking treatment for mood disorders like depression indicate that obesity andoverweight are common problems in these groups 2, 3.