The role of ventromedial prefrontal cortex in anxiety and emotional resilience

The study of brain correlates of emotion in humans has posed a persistent challenge, in part because:a) it is difficult to manipulate and maintain strong emotional statesb) the analysis of state-effects is complicated by low-frequency drift and difficulties in specifying precisely what cognitive and affective operations may give rise to state-related brain activity.In this study, we induced an emotional state using a silent public speech-preparation task that has been shown to provoke anxiety.