Previous investigations of whole thalamus and thalamic nuclei volumes in post-trauma psychopathology have been sparse, limited in scope, and yielded inconsistent results. To address this, volumetric estimates of whole thalamus and thalamic nuclei were obtained from structural brain MRI scans from 2,058 participants across 20 worldwide sites in the ENIGMA PTSD working group.

Background: Since the beginning of Russia’s offensive war against Ukraine, over 6.3 million forcibly displaced persons (FDPs) have settled in the European Union. This study aimed to identify key mental health and psychosocial challenges among Ukrainian forcibly displaced persons (FDPs), including symptoms of depression, anxiety and PTSD, as well as barriers to implementing mental health and psychosocial support (MHPSS) in Poland, Romania, and Slovakia.

Background: A significant proportion of patients with posttraumatic stress disorder (PTSD) do not respond sufficiently to trauma treatment. To date, it has not been clearly demonstrated which patients respond well and which do not.

Objective: This study examined whether lifetime direct and interpersonal trauma exposure as well as the four distinct symptom clusters of PTSD were associated with treatment outcome.

The increasing scale and complexity of neuroimaging datasets aggregated from multiple study sites present substantial analytic challenges, as existing statistical analysis tools struggle to handle missing voxel-data, suffer from limited computational speed and inefficient memory allocation, and are restricted in the types of statistical designs they are able to model.