A substantial body of research shows that adverse life experiences contribute to both psychological and biomedical pathology. Twenty-four randomized controlled trials support the positive effects of eye movement desensitization and reprocessing therapy in the treatment of emotional trauma and other adverse life experiences relevant to clinical practice. Twelve randomized studies of the eye movement component noted rapid decreases in negative emotions and/or vividness of disturbing images

Research has indicated that childhood maltreatment is associated with youth substance use problems, however, this association is not yet fully understood. Consistent with theories that describe substance use problems as reflecting impaired self-regulation abilities, we hypothesized that complex posttraumatic stress disorder (Complex PTSD), reflecting disruptions in the development of self-regulatory capacities, would mediate the association between maltreatment and substance use problem severity.

AbstractBackgroundAn important biological factor suggested in the pathophysiology of (recurrent) Major Depressive Disorder (MDD) concerns a polymorphism in a gene encoding for the MTHFR-enzyme of the one-carbon (1-C)-metabolism.

Posttraumatic stress disorder (PTSD) is associated with a reduced ratio of na+»ve cytotoxic T lymphocytes, an increased ratio of memory cytotoxic T lymphocytes, and a reduced proportion of FoxP3+ regulatory T lymphocytes. This study investigated whether these immunological alterations are reversible through an evidence-based psychotherapeutic treatment. Therefore, 34 individuals with PTSD were randomly assigned to either a treatment condition of 12 sessions Narrative Exposure Therapy (NET) or a waitlist control (WLC) group.