Resting state functional connectivity of the anterior cingulate cortex in veterans with and without post-traumatic stress disorder

Post-traumatic stress disorder (PTSD) is an anxiety disorder that is associated with structural and functional alterations in several brain areas, including the anterior cingulate cortex (ACC). Here, we examine resting state functional connectivity of ACC subdivisions in PTSD, using a seed-based approach. Resting state magnetic resonance images were obtained from male veterans with (n = 31) and without (n = 25) PTSD, and healthy male civilian controls (n = 25).

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Reward functioning in PTSD: A systematic review exploring the mechanisms underlying anhedonia

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric disorder. An important diagnostic feature of PTSD is anhedonia, which may result from deficits in reward functioning. This has however never been studied systematically in PTSD. To determine if PTSD is associated with reward impairments, we conducted a systematic review of studies in which reward functioning was compared between PTSD patients and healthy control participants, or investigated in relation to PTSD symptom severity.

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Rape Survivors' Trauma-Related Beliefs Before and After Cognitive Processing Therapy: Associations with PTSD and Depression Symptoms

This study examined whether cognitive distortions (i.e., assimilated and overaccommodated thoughts) and realistic (i.e., accommodated) thoughts assessed from impact statements written 5-10 years after completing cognitive processing therapy (CPT) accurately predicted posttreatment maintenance or decline in treatment gains during the same period. The sample included 50 women diagnosed with posttraumatic stress disorder (PTSD) secondary to rape who participated in a randomized clinical trial of CPT for PTSD.

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Pre-deployment differences in glucocorticoid sensitivity of leukocytes in soldiers developing symptoms of PTSD, depression or fatigue persist after return from military deployment

Deployed soldiers are at risk of developing stress-related conditions, including posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and severe fatigue. We previously observed condition- and cell-specific differences in sensitivity of immune cells for regulation by glucocorticoids (GCs) pre-deployment between male soldiers with and without subsequent development of high levels of these stress-related symptoms. Here we investigated whether these pre-deployment dysregulations in GC-sensitivity of immune cells persisted after return from military deployment.

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Predicting Suicides After Psychiatric Hospitalization in US Army Soldiers: The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS)

IMPORTANCE: The US Army experienced a sharp increase in soldier suicides beginning in 2004. Administrative data reveal that among those at highest risk are soldiers in the 12 months after inpatient treatment of a psychiatric disorder. OBJECTIVE: To develop an actuarial risk algorithm predicting suicide in the 12 months after US Army soldier inpatient treatment of a psychiatricdisorder to target expanded posthospitalization care.

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Personality traits as predictors of trauma-related coping self-efficacy: A three-wave prospective study

Aim of the present three-wave study was to examine to what extent personality traits and general self-efficacy measured before exposure to a potentially traumatic event (PTE) prospectively predict coping self-efficacy (CSE) perceptions, and to test whether outcomes are biased by the timing of assessment of personality traits. The study was conducted within a large probability-based multi-wave representative internet panel in the Netherlands (Ntotal = 1154)

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Neural correlates of trauma-unrelated emotional processing in war veterans with PTSD

Background Post-traumatic stress disorder (PTSD) is thought to be characterized by general heightened amygdala activation. However, this hypothesis is mainly based on specific studies presenting fear or trauma-related stimuli, hence, a thorough investigation of trauma-unrelated emotional processing in PTSD is needed.Methods In this study, 31 male medication-naive veterans with PTSD, 28 male control veterans (combat controls, CC) and 25 non-military men (healthy controls, HC) were included.

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Neural and genetic markers of vulnerability to posttraumatic stress symptoms among survivors of the World Trade Center attacks

Although recent research has begun to describe the neural and genetic processes underlying variability in responses to trauma, less is known about how these processes interact. We addressed this issue by using functional magnetic resonance imaging (fMRI) to examine the relationship between post-traumatic stress symptomatology (PTSS), a common genetic polymorphism of the serotonin transporter (5-HTT) gene, and neural activity in response to viewing images associated with the 9/11 terrorist attack among a rare sample of high-exposure 9/11 survivors (n=17).

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Loss of social resources predicts incident posttraumatic stress disorder during ongoing political violence within the Palestinian Authority

Background Exposure to ongoing political violence and stressful conditions increases the risk of post traumatic stress disorder (PTSD) in low-resource contexts. However, much of our understanding of the determinants of PTSD in these contexts comes from cross-sectional data. Longitudinal studies that examine factors associated with incident PTSD may be useful to the development of effective prevention interventions and the identification of those who may be most at-risk for the disorder.

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Mental disorders, comorbidity and pre-enlistment suicidal behavior among new soldiers in the US Army: Results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS)

We examined the associations between mental disorders and suicidal behavior (ideation, plans, and attempts) among new soldiers using data from the New Soldier Study (NSS) component of the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS, N = 38,507). Most new soldiers with a pre-enlistment history of suicide attempt reported a prior mental disorder (59.0%). Each disorder examined was associated with increased odds of suicidal behavior (ORs = 2.6GÇô8.6).

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