Randomized controlled trial of multimodular motion-assisted memory desensitization and reconsolidation (3MDR) for male military veterans with treatment-resistant post-traumatic stress disorder

Objective: To explore the potential efficacy of multi-modular motionassisted memory desensitization and reprocessing (3MDR) in British military veterans with treatment-resistant service-related PTSD.

Methods: Exploratory single-blind, randomized, parallel arm, crossover controlled trial with nested process evaluation to assess fidelity, adherence and factors that influence outcome.

Results: A total of 42 participants (all male) were randomized with 83% retention at 12 weeks and 86% at 26 weeks. The difference in mean Clinician-Administered PTSD Scale for DSM-5 scores between the immediate and delayed 3MDR arms was -9.38 (95% CI -17.33 to -1.44, P = 0.021) at 12 weeks and -3.59 (-14.39 to 7.20, P = 0.513) at 26 weeks when both groups had received 3MDR. The likely effect size of 3MDR was found to be 0.65. Improvements were maintained at 26-week follow-up. 3MDR was found to be acceptable to most, but not all, participants. Several factors that may impact efficacy and acceptability of 3MDR were identified.

Conclusion: 3MDR is a promising new intervention for treatmentresistant PTSD with emerging evidence of effect.



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Reference: 
Bisson JI, van Deursen R, Hannigan B, Kitchiner N, Barawi K, Jones K, Pickles T, Skipper J, Young C, Abbott LR, van Gelderen M, Nijdam MJ, Vermetten E. | 2020
In: Acta Psychiatria Sandinavia ; ISSN: 1600-0447 | 142 | 2 | august | 141-151
https://doi.org/10.1111/acps.13200
Open Access
Keywords: 
3MDR (Military Motion Memory Desensitization and Reprocessing) (en), EMDR, EMDR (Eye Movement Desensitization and Reprocessing), Males, Posttraumatic Stress Disorder, Psychotrauma, PTSD (DSM-5), PTSD (en), Randomized Clinical Trial, Treatment, Veterans
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