Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD
Alterations in the number and functional status of mineralocorticoid (MR) and glucocorticoid receptors (GR) may contribute to vulnerability to posttraumatic stress disorder (PTSD). Corticosteroid receptors are chaperoned by heat shock proteins Hsp90 and Hsp70. We examined relations between corticosteroid receptor and heat shock protein expression levels, and related them with war trauma exposure, PTSD and resilience to PTSD. Relative levels of MR, Hsp90 and Hsp70 were determined by immunoblotting in lymphocytes from war trauma-exposed men with current PTSD (current PTSD group, n=113), with life-time PTSD (life-time PTSD group, n=61) and without PTSD (trauma control group, n=88), and from non-traumatized healthy controls (healthy control group, n=85). Between-group differences in MR, Hsp90 and Hsp70 levels and in MR/GR ratio were not observed. The level of MR was correlated with both Hsp90 and Hsp70 levels in trauma control and healthy control groups. On the other hand, GR level was correlated only with Hsp90 level, and this correlation was evident in current PTSD and trauma control groups. In conclusion, PTSD and exposure to trauma are not related to changes in lymphocyte MR, Hsp90 or Hsp70 levels, but may be associated with disturbances in corticosteroid receptors interaction with heat shock proteins. Copyright © 2013 Published by Elsevier Ireland Ltd
Geachte bezoeker,
De informatie die u nu opvraagt, kan door psychotraumanet niet aan u worden getoond. Dit kan verschillende redenen hebben,
waarvan (bescherming van het) auteursrecht de meeste voorkomende is. Wanneer het mogelijk is om u door te verwijzen naar de bron
van deze informatie, dan ziet u hier onder een link naar die plek.
Als er geen link staat, kunt u contact opnemen met de bibliotheek,
die u verder op weg kan helpen.
Met vriendelijke groet,
Het psychotraumanet-team.
Reference:
Matic G,Vojnovic MD,Nestorov J,Elakovic I,Manitasevic JS,Elzaedi YM,Perisic T,Dunderski J,Damjanovic S,Knezevic G,Spiric Z,Vermetten E,Savic D, | 2014
Psychiatry Research | 215 | 2 | february | 379-385
http://ovidsp.ovid.com/ovidweb.cgi
Psychiatry Research | 215 | 2 | february | 379-385
http://ovidsp.ovid.com/ovidweb.cgi
Affiliation author(s):