Interventions on mental health and psychosocial wellbeing have been largely implemented in low and middle income countries. In order to adapt the support offered, an increasing number of applied research projects in mental health and psychosocial support have been conducted. However, while challenges arising can be related to the specificity of the mental health and psychosocial sector, within a broader perspective they are also strongly linked to difficulties of access to beneficiaries, security and protections issues, and competence of staff.