This letter provides an update on the activities of “The Global Collaboration on Traumatic Stress” (GC-TS) as first described by Schnyder et al. in 2017. It presents in further detail the projects of the first theme, in particular the development of and initial data on the Global Psychotrauma Screen (GPS), a brief instrument designed to screen for the wide range of potential outcomes of trauma.

Literature suggests that the occurrence of psychological trauma (PT) fromvariousnegativelifeexperiences beyond events mentioned in the DSM-criterion A, receives little to no attention whencomorbid with psychosis. In fact, despite research indicating the intricate interplay between PTand psychosis, and the need for trauma-focused interventions (TFI), there continue to be mixedviews on whether treating PT would worsen psychosis, with many practitioners hesitating toinitiate treatment for this reason.

N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids. Using a high-throughput screen, chemical proteomics and targeted lipidomics, we report here the discovery and characterization of LEI-401 as a CNS-active N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor.

Background
Ethnic minority groups in Western countries face an increased risk of psychotic disorders. Causes of this long-standing public health inequality remain poorly understood. We investigated whether social disadvantage, linguistic distance and discrimination contributed to these patterns.

Methods