Ketamine for the treatment of mental health and substance use disorders : comprehensive systematic review

Background

In the past twodecades,subanaestheticdosesofketaminehave been demonstrated to have rapid and sustained antidepressant effects, and accumulating research has demonstrated ketamine’s therapeutic effects for a range of psychiatric conditions.

 

Aims

In light of these findings surrounding ketamine’s psychotherapeutic potential, we systematically review the extant evidence on ketamine’s effects in treating mental health disorders.

 

Method

Treating Trauma-related Disorders in Later Life : Moving Forward

Among stress-related disorders, post-traumatic stress disorder (PTSD) takes a central position. Although the percentage of older adults suffering from this condition appears to be lower than among younger adults, PTSD among them often presents a serious condition with high comorbidity rates. In this contribution, recent insights into post-traumatic stress disorder among older people as well as psychotherapeutic treatments are discussed. In particular, the results of recently completed investigations are discussed.

 

Acute stress reactivity and intrusive memory development : a randomized trial using an adjusted trauma film paradigm

Understanding the neurobiological and cognitive processes underlying the development of posttraumatic stress disorder (PTSD) and its specific symptoms may facilitate preventive intervention development. Severe traumatic stress and resulting biological stress system activations can alter contextual memory processes. This may provide a neurobiological explanation for the occurrence of intrusive memories following trauma.

Hair Cortisol in Service Dogs for Veterans with Post-traumatic Stress Disorder Compared to Companion Dogs (Canis Familiaris)

Service dogs are trained to assist humans. This assistance potentially exposes them to stressors To investigate if service dogs are exposed to more stressors than companion dogs we questioned whether hair cortisol levels differed between both groups.

 

We studied this by cutting a tuft of hair from the neck of 19 companion and 11 service dogs. Cortisol levels were subsequently analyzed via immunoassay and compared via a simple linear regression model. The influence of coat color, season, sex, other dogs, pets, or mental health diagnoses in the household was also checked .

Psychopathology and resilience in older adults with posttraumatic stress disorder : a randomized controlled trial comparing narrative exposure therapy and present-centered therapy

Objective: Using data from a randomized controlled trial on psychotherapy for posttraumatic stress disorder (PTSD) in older adults (aged >55), this study aimed at analysing the efficacy of two psychological interventions in terms of self-reported symptoms, comorbid  psychopathology and resilience outcomes.

 

Video intervention to increase treatment-seeking by healthcare workers during the COVID-19 pandemic : randomised controlled trial

Background
Many healthcare workers do not seek help, despite their enormous stress and greater risk for anxiety, depression and post-traumatic stress disorder (PTSD).

 

Aims
This study screened for psychopathology and evaluated the efficacy of a brief, social contact-based video intervention in increasing treatment-seeking intentions among healthcare workers (trial registration: NCT04497415). We anticipated finding high rates of psychopathology and greater treatment-seeking intentions post-intervention.

 

Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information.

Background
Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) information could enhance the discovery power of PTSD genome-wide association studies (GWASs).
 

What is good grief support? : Exploring the actors and actions in social support after traumatic grief

Social support seems to enhance wellbeing and health in many populations. Conversely, poor social support and loneliness are a social determinant of poor health outcomes and can adversely affect physical, emotional, and mental well-being. Social support is especially important in traumatic grief. However, the ways in which grieving individuals interpret and define social support is not well understood, and little is known about what specific behaviours are perceived as helpful.

 

Moving Toward and Through Trauma : Participant Experiences of Multi-Modal Motion-Assisted Memory Desensitization and Reconsolidation (3MDR)

Introduction: Military members and Veterans are at risk of developing combat-related, treatment-resistant posttraumatic stress disorder (TR-PTSD) and moral injury (MI). Conventional trauma-focused therapies (TFTs) have shown limited success. Novel interventions including Multi-modal Motion-assisted Memory Desensitization and Reconsolidation therapy (3MDR) may prove successful in treating TR-PTSD.

 

Objective: To qualitatively study the experiences of Canadian military members and Veterans with TR-PTSD who received the 3MDR intervention.

Tailored immersion : implementing personalized components into virtual reality

With the application of virtual reality (VR), tailored interventions can be created that mirror the traumatic experiences of veterans with post-traumatic stress disorder (PTSD). Visual elements can be mimicked, and auditory and other senses stimulated. In doing so, the degree of immersion can be adjusted to optimize the therapeutic process.

 

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