Is the Requirement for First-Person Experience of Psychedelic Drugs a Justified Component of a Psychedelic Therapist’s Training?

Recent research offers good reason to think that various psychedelic drugs—including psilocybin, ayahuasca, ketamine, MDMA, and LSD—may have significant therapeutic potential in the treatment of various mental health conditions, including post-traumatic stress disorder, depression, existential distress, and addiction. Although the use of psychoactive drugs, such as Diazepam or Ritalin, is well established, psychedelics arguably represent a therapeutic step change. As experiential therapies, their value would seem to lie in the subjective experiences they induce.

Perspectives on dying in severe and enduring eating disorders (SEEDs) : A qualitative study among Dutch mental healthcare providers

Dying of severe and enduring eating disorders (SEEDs) was studied using semi-structured interviews (n=7) and a follow-up videoconferencing focus group (n=3) with Dutch mental healthcare providers. We identified three main themes: the uncertainties of dying from SEEDs, dilemmas in defining treatment resistance and palliative care, and suicidal ideation and intent.


Self-guided online treatment of disturbed grief, posttraumatic stress, and depression in adults bereaved during the COVID-19 pandemic : A randomized controlled trial

This randomized-waitlist controlled trial is the first study examining short-term effects of a self-guided online grief-specific cognitive behavioral therapy (CBT) in reducing early persistent complex bereavement disorder (PCBD), posttraumatic stress disorder (PTSD), and depression symptoms in adults bereaved during the COVID-19 pandemic.


Changes in trauma-related cognitions predict subsequent symptom improvement during prolonged exposure in patients with childhood abuse-related PTSD

Change in negative posttraumatic cognitions is a proposed mechanism through which Prolonged Exposure (PE) leads to symptom reduction of posttraumatic stress disorder (PTSD). A strong case for posttraumatic cognitions as a change mechanism in PTSD treatment can be made by establishing temporal precedence of change in cognitions. The current study examines the temporal relationship between change in posttraumatic cognitions and PTSD symptoms during PE, using the Posttraumatic Cognitions Inventory.

Editorial : Emerging treatments and approaches for moral injury and moral distress

Current evidence-based therapies to treat trauma-affected populations, especially military members and first responders, have had variable success. Treatment response may be impeded by a lack of clinical attention to moral aspects of psychotrauma.

A balancing act : caring for ‘difficult’ patients in community mental health nursing = Een evenwichtsoefening : geven om ‘moeilijke’ patiënten in de sociaal psychiatrische verpleegkunde

Het algemene doel van dit proefschrift was het verkennen en evalueren van nieuwe en methodische manieren om de langdurige behandeling van patiënten met een ernstige niet-psychotische psychiatrische aandoening, die door hun sociaal-psychiatrisch verpleegkundigen als moeilijk worden ervaren, te verbeteren. Daarbij was het belangrijk om inzicht te krijgen in waarom zij als moeilijk worden ervaren. Hoewel er verschillende antwoorden op de onderzoeksvragen zijn verkregen, komen er nieuwe en fundamentele vragen naar voren over de zorg voor deze groep patiënten. 




Epigenetics of traumatic stress : The association of NR3C1 methylation and posttraumatic stress disorder symptom changes in response to narrative exposure therapy

Epigenetic processes allow plasticity in gene regulation in response to significant environmental events. Accumulating evidence suggests that effective psychotherapy is accompanied by epigenetic changes, rendering DNA methylation a potential biomarker of therapy success. Due to the central role of glucocorticoid dynamics in stress regulation and the alteration of aversive memories, glucocorticoid receptors are likely involved in the molecular processes that are required to successfully treat Posttraumatic Stress Disorder (PTSD).


The impact of trauma-focused psychotherapy for posttraumatic stress disorder on interpersonal functioning : A systematic review and meta-analysis of randomized clinical trials

Interpersonal functioning is a common concern for people with postttraumatic stress disorder (PTSD) but is not a key target of most trauma-focused psychotherapies (TFPs). We preregistered and undertook a systematic review and meta-analysis of randomized clinical trials (RCTs) examining the efficacy of TFPs for improving interpersonal functioning. Studies were identified through the PTSD Trials Standardized Data Repository, scholarly databases, and the solicitation of unpublished data from the PTSD research community following current PRISMA guidelines.


Dialectical behaviour therapy for posttraumatic stress disorder (DBT-PTSD) : transportability to everyday clinical care in a residential mental health centre

Background: Dialectical Behaviour Therapy for Posttraumatic Stress Disorder (DBT-PTSD) is a phase-based treatment for PTSD. The DBT-PTSD treatment programme’s efficacy has not been tested during standard operation, outside of laboratory outcome studies.


Objective: The present pilot study investigated the transportability of the DBT-PTSD treatment to a real word clinical setting in a residential mental health centre.