Response of young patients with probable ICD-11 complex PTSD to treatment with developmentally adapted cognitive processing therapy

Background: ICD-11 features Complex Posttraumatic Stress Disorder (CPTSD) as a new diagnosis. To date, very few studies have investigated CPTSD in young patients, and there is a need for evidence on effective treatment.


Objective: The present study evaluates the applicability of developmentally adapted cognitive processing therapy (D-CPT) for CPTSD in young patients in a secondary analysis of the treatment condition of a randomized controlled trial (RCT) investigating the efficacy of D-CPT.


Methods: The D-CPT treatment group in the original study included 44 patients (14–21 years) with DSM-IV PTSD after childhood abuse. We used the ICD-11 algorithm to divide the sample into a probable CPTSD and a non-CPTSD group. We performed multilevel models for interviewer-rated and self-rated PTSD symptoms with fixed effects of group (CPTSD, non-CPTSD) and time (up to 12 months follow-up) and their interaction. Treatment response rates for both groups were calculated.


Results: Nineteen (43.2%) patients fulfilled criteria for probable ICD-11 CPTSD while 25 (56.8%) did not. Both CPTSD and non-CPTSD groups showed symptom reduction over time. The CPTSD group reported higher symptom severity before and after treatment. Linear improvement and treatment response rates were similar for both groups. D-CPT reduced symptoms of disturbances in self-regulation in both groups.


Discussion: Both, patients with and without probable ICD-11 CPTSD seemed to benefit from D-CPT and the treatment also reduced disturbances in self-regulation.


Conclusion: This study presents initial evidence of the applicability of D-CPT in clinical practice for young patients with CPTSD. It remains debatable whether CPTSD implies different treatment needs as opposed to PTSD.



  • We investigated the applicability of developmentally adapted cognitive processing therapy (D-CPT) to reduce PTSD symptoms in abused young patients with and without probable CPTSD.


  • Findings showed significant reduction of PTSD symptoms in both groups and results remained stable over a 12-month follow-up period.
Rebekka Eilers, Eline Rimane, Anna Vogel, Babette Renneberg, Regina Steil, and Rita Rosner | 2021
In: European Journal of Psychotraumatology ; ISSN: 2000-8066 | 12 | 1 | april | 1929024
Adolescents, Child Abuse, Cognitive Processing Therapy, Complex PTSD, Effects, Posttraumatic Stress Disorder, Psychotrauma, PTSD (DSM-5), PTSD (en), PTSD (ICD-11), Research, Treatment