Major Depressive Disorder (MDD) is a highly recurrent disease. Stress-responsive system dysfunction seems to persist after remission. In patients with more chronic and recurrent depressive episodes, state related HPA-axis dysregulation might be a risk factor for prospective recurrence. This study examines the predictive effect of cortisol on consecutive episodes in remitted recurrently depressed...

A search along the Burma-Thailand Railway 65 years later- The heavy work on this railroad started in June 1942 and, after 415 kilometers, 16 months later, was completed in October 1943. Much has disappeared or changed in recent decades: the remaining tracks will disappear by the ravages of time. Like the people who worked on it. A piece of 'real' history is slowly disappearing. This publication...

Lost in Srebrenica is an interdisciplinary PhD thesis in the areas of Dutch/UN Peacekeeping in Srebrenica, international politics, genocide studies, ethics and foreign politics, international law and history. The events in Srebrenica are still haunting international politics as “Europe’s Worst Massacre since the Second World War,” as can be illustrated by the new and old Srebrenica issues...

The first wave of research on loss and potentially traumatic events (PTEs) was dominated by either a psychopathological approach emphasizing individual dysfunction or an event approach emphasizing average differences between exposed and nonexposed groups. We consider the strengths and limitations of these approaches and then review more recent research that has focused on the heterogeneity of...

BackgroundHypothalamic-pituitary-adrenal (HPA)-axis hyperactivity has been observed in (recurrent) major depressive disorder (MDD), although inconsistently and mainly cross-sectional. Longitudinal studies clarifying state-trait issues are lacking. We aimed to determine whether HPA-axis (hyper)activity in recurrent MDD is: (I) reflecting a persistent trait, (II) influenced by depressive state, (...

Background: The prevalence of 30-day mental disorders with retrospectively reported early onsets is significantly higher in the U.S. Army than among sociodemographically matched civilians. This difference could reflect high prevalence of preenlistment disorders and/or high persistence of these disorders in the context of the stresses associated with military service. These alternatives can to...

L'irruption de la vie d'un nouvel être dans l'univers familial est un événement traumatique méconnu. Pour l'adulte à qui échoit la responsabilité de l'accueillir, il est fréquent que l'épreuve soit difficilement surmontable, selon les dimensions imaginaires, symboliques ou réelles que revêtira pour lui cette confrontation. En ce sens, les 'lieux' du traumatisme seront différents à chaque fois et...

Dit is al weer de derde bundel in de reeks Lessen uit crises en mini-crises. In de zeventien hoofdstukken die hierna volgen wordt een selectie van bijzondere gebeurtenissen uit het jaar 2014 belicht. Het oogmerk waarmee deze gebeurtenissen zijn samengebracht, is het ontrafelen van dilemma’s; de kwesties die op dat moment speelden, hetzij bestuurlijk of operationeel. Langs die weg hopen wij een...

»Euthanasia« was the cynical euphemism used by the Nazis to refer to the systematic extermination of hundreds of thousands of mentally sick and handicapped people between 1939 and 1945. Today, many of the victims, including patients at the Rostock Psychiatric and Neurological Hospital, are no more than figures on a statistics sheet. Accordingly, it is quite rare for individual fates to be taken...