Background

Posttraumatic stress disorder (PTSD) is a complex and debilitating anxiety disorder, and, although prolonged exposure therapy has been proven effective, many patients remain symptomatic after treatment. In other anxiety disorders, the supplementary use of d-cycloserine (DCS), a partial agonist at the glutamatergic N-methyl-D-aspartate receptor, showed promise in enhancing treatment effects. We examined whether augmentation of prolonged exposure therapy for PTSD with DCS enhances treatment efficacy.

Methods

This unique volume presents the experience of 37 U.S. military nurses sent to the Iraq and Afghanistan theaters of war to care for the injured and dying. The personal and professional challenges they faced, the difficulties they endured, the dangers they overcame, and the consequences they grappled with are vividly described from deployment to discharge. In mobile surgical field hospitals and...

Major Depressive Disorder (MDD) is a highly recurrent disease. Stress-responsive system dysfunction seems to persist after remission. In patients with more chronic and recurrent depressive episodes, state related HPA-axis dysregulation might be a risk factor for prospective recurrence. This study examines the predictive effect of cortisol on consecutive episodes in remitted recurrently depressed...

The first wave of research on loss and potentially traumatic events (PTEs) was dominated by either a psychopathological approach emphasizing individual dysfunction or an event approach emphasizing average differences between exposed and nonexposed groups. We consider the strengths and limitations of these approaches and then review more recent research that has focused on the heterogeneity of...