BackgroundIt is unknown to what extent acculturation among disaster-affected immigrants is associated with mental health problems (MHP) compared to non-affected immigrants.MethodsWe examined the associations between acculturation and post-disaster MHP among affected and non-affected immigrants in The Netherlands.ResultsAmong the affected group, keeping norms and values of original culture and limited skills to cope with the demands of the new society were independently associated with PTSD-symptomatology, anxiety, depression, hostility, and somatic problems at 18 months post-event.