Background: A reciprocal relationship between activated innate immune system and changes in mood and behavior has been established. There is still a paucity of knowledge on how the immune system responds during psychiatric treatment. We aimed to explore circulating cytokines and assess psychiatric symptom severity scores during 12 weeks of inpatient psychiatric treatment.

Highlights

•Psychometric properties of DSM-5 PCBD and ICD-11 PGD have not been previously compared.

•A three-factor model of PCBD and a two-factor model of PGD yielded acceptable fit.

•The prevalence of probable PCBD (6.4%) was significantly lower than PGD (18.0%).

•Predictive validity differed between PCBD and PGD.

•Findings provide preliminary evidence for the validity of PCBD and PGD.

PTSD can be caused by a range of experiences, from a car crash to rape to surviving a terrorist attack. But how do you know if you have it and what can you do?

Animal and human studies have shown that both early-life traumatic events and ongoing stress episodes affect neurodevelopment, however, it remains unclear whether and how they modulate normative adolescent neuro-maturational trajectories. We characterized effects of early-life (age 0–5) and ongoing stressors (age 14–17) on longitudinal changes (age 14 to17) in grey matter volume (GMV) of healthy adolescents (n = 37). Timing and stressor type were related to differential GMV changes.