The oxytocinergic system in PTSD following traumatic childbirth: endogenous and exogenous oxytocin in the peripartum period

Birth experiences can be traumatic and may give rise to PTSD following childbirth (PTSD-FC). Peripartum neurobiological alterations in the oxytocinergic system are highly relevant for postpartum maternal behavioral and affective adaptions like bonding and lactation but are also implicated in the response to traumatic events. Animal models demonstrated that peripartum stress impairs beneficial maternal postpartum behavior. Early postpartum activation of the oxytocinergic system may, however, reverse these effects and thereby prevent adverse long-term consequences for both mother and infant.

Oxytocin receptor gene methylation in male and female PTSD patients and trauma-exposed controls

Oxytocin receptor gene (OXTR) DNA-methylation levels have been associated with traumaexposure, mood- and anxiety disorders, and social processes relevant to posttraumatic stress disorder (PTSD). We hypothesized that OXTR methylation may play a role in the neurobiological underpinnings of PTSD. In the current study, we compared OXTR methylation between PTSD patients (n = 31, 14 females) and trauma-exposed controls (n = 36, 19 females).

Trauma and Public Mental Health : A Focused Review

Psychological trauma has developed into a very common concept in the scientific community, in mental health care, as well as in popular language and mass media. The purpose of this article is to show the relevance of the discipline of traumatic stress studies to the field of public mental health by examining central concepts and findings concerning trauma and its aftermath and examining implications for public mental health.

Traumatic loss: Mental health consequences and implications for treatment and prevention

Traumatic loss involves the loss of loved ones in the context of potentially traumatizing circumstances and is a commonly reported traumatic event. It may give rise to disturbed grief, called prolonged grief disorder (PGD) in ICD-11 and persistent complex bereavement disorder (PCBD) in DMS-5, combined with posttraumatic stress disorder (PTSD) and depression. The recent inclusion of grief disorders in both DSM-5 and ICD-11 have spurred research on grief-related psychopathology. This special issue on traumatic loss includes 10 articles and two letters.

Conducting research in clinical practice : Challenges in the assessment and treatment of childhood internalizing disorders

Dissertation: Radboud Universiteit Nijmegen

Vanuit de Academische Werkplaats Inside-Out onderzocht Marleen van Doorn de diagnostiek en behandeling van kinderen met angst of depressieve klachten in de klinische praktijk. Bij het stellen van een diagnose is het essentieel dat therapeuten niet alleen de visie van ouders op zulke klachten meewegen, maar ook die van het kind zelf, is een belangrijke conclusie uit het promotieonderzoek.

Onopgemerkte stoornissen 

No pain, no gain: cross-lagged analyses of posttraumatic growth and anxiety, depression, posttraumatic stress and prolonged grief symptoms after loss

Background and objectives: Major negative life-events including bereavement can precipitate perceived positive life-changes, termed posttraumatic growth (PTG). While traditionally considered an adaptive phenomenon, it has been suggested that PTG represents a maladaptive coping response similar to cognitive avoidance. To clarify the function of PTG, it is crucial to establish concurrent and longitudinal associations of PTG with post-event mental health problems. Yet, longitudinal studies on this topic are scarce. The present study fills this gap in knowledge.

Manual on community-based mental health and psychosocial support in emergencies and displacement

This Manual aims to facilitate mental health and psychosocial support (MHPSS) experts and managers in designing, implementing and evaluating community-based MHPSS (CB MHPSS) programmes, projects and activities for emergency-affected and displaced populations in humanitarian settings. It is specifically designed to support managers and experts hired by the International Organization for Migration (IOM).

Differentiating PTSD from anxiety and depression : Lessons from the ICD‐11 PTSD diagnostic criteria

Objective
Posttraumatic stress disorder (PTSD) is frequently associated with depression and anxiety, but the nature of the relationship is unclear. By removing mood and anxiety diagnostic criteria, the 11th edition of the International Classification of Diseases (ICD‐11) aims to delineate a distinct PTSD phenotype. We examined the effect of implementing ICD‐11 criteria on rates of codiagnosed depression and anxiety in survivors with recent PTSD.

 

Associations between perceived social support, posttraumatic stress disorder (PTSD) and complex PTSD (CPTSD) : implications for treatment

ABSTRACT

 

Background:

Perceived social support (PSS) is one of the most important risk factors for the onset and maintenance of posttraumatic stress disorder (PTSD) symptoms, however the relationship between PSS and Complex PTSD (CPTSD) is unknown. The evidence-base for CPTSD treatment is currently lacking, though increasingly important given the recent publication of the ICD-11, which now allows for a formal diagnosis of CPTSD.

 

Objective:

Prevalence and course of subthreshold anxiety disorder in the general population : A three-year follow-up study

 

Highlights

•In the general population the prevalence of subthreshold anxiety disorders is 11.4%.

 

•Subthreshold anxiety disorders have a heterogeneous three-year course.

 

•In 57.3% of respondents subthreshold anxiety symptoms are self-limiting.

 

•Symptoms were persistent in 29.0% and progressed into an anxiety disorder in 13.8%.

 

•People with persistent or progressive anxiety symptoms may benefit from intervention.

 

Abstract

 

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