Background: Major Depressive Disorder (MDD) in adolescence has a high prevalence and risk of disability, but current treatments show limited effectiveness and high drop-out and relapse rates. Although the role of distressing experiences that relate to the development and maintenance of MDD has been recognized for decades, the efficacy of a trauma-focused treatment approach for MDD has hardly been studied.

The focus of this study is the WHO’s mhGAP-Intervention Guide (mhGAP-IG)2.0 (2016), an evidence-based tool and guideline to help detect, diagnose andmanage the most common mental disorders, designed for use by non-specialistsglobally but particularly in low- and middle-income countries. This research is astarting point in tracing the multiple‘doings’of mhGAP-IG–connectingquestions of how it is‘done’and what does it‘do’–to the living histories andwider global mental health assemblages that make the tool possible and shape itsglobal circulation.

Are you feeling anxious? Did you sleep poorly last night? Sleep disruption is a recognized feature of all anxiety disorders. Here, we investigate the basic brain mechanisms underlying the anxiogenic impact of sleep loss. Additionally, we explore whether subtle, societally common reductions in sleep trigger elevated next-day anxiety. Finally, we examine what it is about sleep, physiologically, that provides such an overnight anxiety-reduction benefit.

Purpose: Prior latent class analyses (LCA) have focused on people who were bereaved more than 6 months earlier. Research has yet to examine patterns and correlates of emotional responses in the frst few months of bereavement. We examined whether subgroups could be identifed among very recently (≤6 months) bereaved adults, based on their endorsement of symptoms of prolonged grief disorder (PGD), posttraumatic stress disorder (PTSD), and depression.