Intranasal oxytocin : miracle cure after trauma?

Background: In popular media and on Internet, the neuropeptide oxytocin is often advertised as a miracle drug that cures all

types of disorders, reduces stress, saves marriages, all conveniently with a nasal spray. Here we will present the effects of intranasal

oxytocin on brain function in recently traumatized individuals and patients with posttraumatic stress disorder (PTSD) and

discuss clinical implications and further research. PTSD is characterized by exaggerated fear responses to threat and traumarelated

Plasma lipoproteins in posttraumatic stress disorder patients compared to healthy controls and their associations with the HPA- and HPT-axis

Abstract

Background

Based on studies among primarily male veteran subjects, lipoproteins are thought to mediate the association of posttraumatic stress disorder (PTSD) with cardiovascular disease (CVD). However, recent civilian studies with female samples or samples with both sexes represented provide little evidence for this association. Gender, diet and sex-specific effects of stress hormones on lipoproteins may explain this dissociation in findings.

Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder : systematic review and meta-analysis of relapse prevention trials

Objectives To examine the risk of relapse and time to relapse after discontinuation of antidepressants in patients with anxiety disorder who responded to antidepressants, and to explore whether relapse risk is related to type of anxiety disorder, type of antidepressant, mode of discontinuation, duration of treatment and follow-up, comorbidity, and allowance of psychotherapy.

 

Design Systematic review and meta-analyses of relapse prevention trials.

 

Scope, Scale, and Dose of the World’s Largest School-Based Mental Health Programs

Untreated mental health problems are among the most disabling, persistent, and costly health conditions.

Because they often begin in childhood and continue into adulthood, there has been growing interest in preventive mental health programs for children.

In recent years, several such programs have been implemented at regional, state, or national scale, and although many experimental studies have documented positive outcomes of individual programs, this article represents the first attempt to systematically compare the largest programs in terms of scope, scale, and dose.

Setting the stage for recovery. Improving veteran PTSD treatment effectiveness using statistical prediction

Over half a million Dutch veterans participated in almost a hundred war and peace keeping missions since 1940. During past deployments, veterans promoted peace and stability in conflict situations, endeavoured to win the hearts and minds of local communities and improved the lives of those affected in warzone circumstances. These men and women operated under harsh conditions that placed them at the vanguard of human violence and tragedy.

Intensive prolonged exposure treatment for adolescent complex posttraumatic stress disorder : a single-trial design

Background

The current study evaluated the effectiveness and safety of intensive prolonged exposure (PE) targeting adolescent patients with complex posttraumatic stress disorder (PTSD) and comorbid disorders following multiple interpersonal trauma.

Dance/Movement therapy and resilience building with female asylum seekers and refugees : a phenomenological practice based research

This phenomenological study aims to better understand the applicability of Dance/Movement therapy for traumatised women asylum seekers and refugees. It explores if and how bodily engagement could support an existing resilience based treatment model employed at a centre for transcultural psychiatry in the Netherlands. The sessions focused on moving the body and included the use of music, props, mirroring techniques, body awareness and movement exploration exercises. Participation in the sessions was associated with self-reported alleviation of stress and addressed vulnerabilities.

Oxytocin receptor gene polymorphisms, attachment, and PTSD : Results from the National Health and Resilience in Veterans Study

The human oxytocin system is implicated in social behavior and stress recovery. Polymorphisms in the oxytocin receptor gene (OXTR) may interact with attachment style to predict stress-related psychopathology like posttraumatic stress disorder (PTSD). The objective of this study was to examine independent and interactive effects of the OXTR single nucleotide polymorphism (SNP) rs53576, which has been associated with stress reactivity, support-seeking, and PTSD in prior studies, and attachment style on risk for PTSD in a nationally representative sample of 2163 European-American (EA) U.S.

Intranasal Oxytocin May Prevent PTSD

Administering a commonly available hormone via a nasal spray could help prevent the development of posttraumatic stress disorder (PTSD) and reduce symptoms in those who already have the condition, results of several clinical studies suggest.

Intranasal oxytocin significantly reduced the likelihood of the development of PTSD among patients in an emergency department (ED) who had a high degree of baseline trauma symptoms, said Miranda Olff, PhD, Department of Psychiatry, Academic Medical Center, University of Amsterdam, the Netherlands.

 

Day patient treatment for traumatic grief: preliminary evaluation of a one-year treatment programme for patients with multiple and traumatic losses

Background: Bereaved individuals who have lost a loved one under traumatic circumstances can develop symptoms of Persistent Complex Bereavement Disorder (PCBD) and/or Posttraumatic Stress Disorder (PTSD). This is particularly common in refugees, as they frequently have been confronted with multiple traumatic losses. For patients with severe PTSD and traumatic grief a treatment programme was developed, embedding individual traumatic grief focused therapy in a group-based multidisciplinary day patient treatment programme.

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