Evaluating the feasibility of complex interventions in mental health services : standardised measure and reporting guidelines.

The feasibility of implementation is insufficiently considered in clinical guideline development, leading to human and financial resource wastage.
To develop (a) an empirically based standardised measure of the feasibility of complex interventions for use within mental health services and (b) reporting guidelines to facilitate feasibility assessment.

Sleep structure and emotional memory processing in police officers and combat veterans with PTSD

Disturbed sleep is one of the key symptoms of posttraumatic stress disorder (PTSD) and may contribute to the genesis and maintenance of PTSD. Our previously published study*, executed in healthy subjects, suggests that adaptive changes occur in sleep architecture, after emotional experiences, that benefit emotional housekeeping and the attenuation of emotional responses to negative emotional experiences. Little is known, however, about the relation between sleep and emotional memory processing in PTSD.

Effects of oxidative stress on fatty acid- and one-carbon-metabolism in psychiatric and cardiovascular disease comorbidity

ObjectiveCardiovascular disease (CVD) is the leading cause of death in severe psychiatric disorders (depression, schizophrenia). Here, we provide evidence of how the effects of oxidative stress on fatty acid (FA) and one-carbon (1-C) cycle metabolism, which may initially represent adaptive responses, might underlie comorbidity between CVD and psychiatric disorders.MethodWe conducted a literature search and integrated data in a narrative review.ResultsOxidative stress, mainly generated in mitochondria, is implicated in both psychiatric and cardiovascular pathophysiology.

Seven-Year Follow-Up Study of Symptoms in Asylum Seekers and Refugees With PTSD Treated With Trauma-Focused Groups

Objective: To examine sustainability of symptom outcomes of a 1-year phase-based traumafocused, multimodal, and multicomponent group therapy in a day treatment program for posttraumatic stress disorder (PTSD) over an average period of 7 years.

Screening and treatment of posttraumatic stress disorder in patients with substance use disorders

Roughly, one out of four patients with a substance use disorder (SUD) also meets criteria for PTSD. Both disorders seem to be highly intertwined. Two chapters of this thesis focus on the development of a screening questionnaire to detect PTSD within substance abuse treatment centers. For this purpose, a PTSD screener from the United States army was used, the Primary Care posttraumatic stress disorder screen (PC-PTSD). Based on the results of this study a new screener was assembled and cross-validated: the Jellinek-PTSD screening questionnaire (J-PTSD).

Mental Disorders as Causal Systems: A Network Approach to Posttraumatic Stress Disorder

Debates about posttraumatic stress disorder (PTSD) often turn on whether it is a timeless, cross-culturally valid natural phenomenon or a socially constructed idiom of distress. Most clinicians seem to favor the first view, differing only in whether they conceptualize PTSD as a discrete category or the upper end of a dimension of stress responsiveness. Yet both categorical and dimensional construals presuppose that PTSD symptoms are fallible indicators reflective of an underlying, latent variable.

Challenges in treatment of posttraumatic stress disorder

Background: Research shows that trauma-focused therapy and multimodal interventions are the two most
often used strategies in treatment of refugees suffering from posttraumatic stress disorder (PTSD). While
preliminary evidence suggests that trauma-focused approaches may have some efficacy, this could not be
established for multimodal interventions. However, it may be that multimodal interventions have been studied
in more treatment-resistant refugees with very high levels of psychopathology, disability, and chronicity. In the

EMDR With Traumatized Refugees: From Experience-Based to Evidence-Based Practice

Many refugees resettled in Western countries suffer from an accumulation of traumatic and current stressors that contribute to mental health problems and may complicate trauma-focused treatment. Consequently, the acceptability, safety, and efficacy of trauma-focused treatment with refugees have been a matter of clinical and scientific interest. In recent years, the evidence has accumulated for narrative exposure therapy and culturally adapted cognitive behavioral therapy.