Equator Foundation


Effects of oxidative stress on fatty acid- and one-carbon-metabolism in psychiatric and cardiovascular disease comorbidity

ObjectiveCardiovascular disease (CVD) is the leading cause of death in severe psychiatric disorders (depression, schizophrenia). Here, we provide evidence of how the effects of oxidative stress on fatty acid (FA) and one-carbon (1-C) cycle metabolism, which may initially represent adaptive responses, might underlie comorbidity between CVD and psychiatric disorders.MethodWe conducted a literature search and integrated data in a narrative review.ResultsOxidative stress, mainly generated in mitochondria, is implicated in both psychiatric and cardiovascular pathophysiology.

Bimodal distribution of fatty acids in recurrent major depressive disorder.

Bentsen et al. (1) recently tested the hypothesis that red blood cell (RBC) polyunsaturated fatty acids (PUFAs) are bimodally distributed in schizophrenia and related psychoses. In their study, sums of total, ?3, and ?6 PUFA concentrations were indeed bimodally distributed, as opposed to one normal distribution for sums of saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs).

Ala54Thr fatty acid-binding protein 2 (FABP2) polymorphism in recurrent depression: associations with fatty acid concentrations and waist circumference

BackgroundFatty acid (FA)-alterations may mediate the mutual association between Major Depressive Disorder (MDD) and cardiovascular disease (CVD). However, etiology of observed FA-alterations in MDD and CVD remains largely unclear. An interesting candidate may be a mutation in the fatty acid–binding protein 2 (FABP2)-gene, because it regulates dietary FA-uptake.

The case of refugees : A case of social bonds.

Having worked with many refugees, Pim Scholte explains the human side of the refugee crisis from the point of view of a psychiatrist. This april  Pim Scholte at the Academiegebouw of the University of Utrecht held a TED talk under the titel: 'The case of refugees. A case of social bonds'. The presentation is part of a yearly series, organised by University colledge Utrecht.

Social capital and mental health: connextions and complexities in contexts of post conflict recovery

In war affected populations there is often severe disruption of societal cohesion. Additionally, grief and traumatisation, along with insufficient health services and a lack of security, give rise to an increase of mental health problems. Social capital is potentially a key resource to support post conflict recovery, and is increasingly considered not merely as a resource supporting economic and social development, but also an important influence on population health. However, linkages between social capital and mental health are complex.

Psychological distress, depression, anxiety, and burnout among international humanitarian aid workers: a longitudinal study

International humanitarian aid workers providing care in emergencies are subjected to numerous chronic and traumatic stressors.

To examine consequences of such experiences on aid workers' mental health and how the impact is influenced by moderating variables.

Trauma-related mental health problems among national humanitarian staff: A systematic review of the literature

Background: Working in humanitarian crisis situations is dangerous. National humanitarian staff in particular face the risk of primary and secondary trauma exposure which can lead to mental health problems. Despite this, research on the mental health of national staff is scarce, and a systematic analysis of up-to-date findings has not been undertaken yet.

Factors affecting mental health of local staff working in the Vanni region, Sri Lanka

In the aftermath of the civil war that extended from 1983–2009, humanitarian organizations provided aid to the conflict-affected population of the Vanni region in northern Sri Lanka. In August, 2010, a needs assessment was conducted to determine the mental-health status of Sri Lankan national humanitarian aid staff working in conditions of stress and hardship, and consider contextual and organizational characteristics influencing such status.