ARQ Centrum’45 (en)


Memory traces of trauma : neurocognitive aspects of and therapeutic approaches for posttraumatic stress disorder

Dit proefschrift gaat over de 'sporen' die een traumatische ervaring in het geheugen heeft gegraveerd ('geheugensporen van trauma') als iemand PTSS heeft ontwikkeld.

Linking post-disaster mental health to the erosion of social fabric

Psychische gevolgen na een natuurramp worden niet alleen bepaald door de traumatische ervaring zelf en de manier waarop individuen omgaan met de gevolgen van de ramp. Zij worden ook bepaald door de destructieve gevolgen van rampen op de context en de sociale gemeenschap waarin getroffen mensen wonen. Het is belangrijk deze complexe factoren te betrekken in rampen-onderzoek. Dit proefschrift wil aantonen dat het kruisvlak tussen individuele variabelen en determinanten in de rampgetroffen context bepaalt of mensen psychische problemen ervaren na een ramp.

Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial

BackgroundCurrently few evidence based interventions are available for the prevention of PTSD within the first weeks after trauma. Increased risk for PTSD development is associated with dysregulated fear and stress responses prior to and shortly after trauma, as well as with a lack of perceived social support early after trauma. Oxytocin is a potent regulator of these processes. Therefore, we propose that oxytocin may be important in reducing adverse consequences of trauma.

Deconstructing delayed posttraumatic stress disorder

The purpose of the research in this book was to establish the prevalence of delayed PTSD and to examine factors that may explain its occurrence. In addition, we aimed at exploring the likelihood and role of prodromal symptoms (symptoms of PTSD that occur during the interval between traumatic event exposure and the onset of full delayed PTSD) and possible implications of delayed PTSD for mental health service utilization.

Coping and chronic psychosocial consequences of female genital mutilation in the Netherlands

Objective. The study presented in this article explored psychosocial and relational problems of African immigrant women in the Netherlands who underwent female genital mutilation/cutting (FGM/C), the causes they attribute to these problems – in particular, their opinions about the relationship between these problems and their circumcision – and the way they cope with these health complaints. Design.

Child in the shadowlands

The World Health Organization described children born of rape as at risk of being neglected, stigmatized, ostracized, or abandoned. Cases of infanticide (the killing of an infant) have also been reported. Despite such general concerns, little is known about the fate of these children. Even in the mental health domain, professional conversations hardly include their fate. Clinical case reports describe a high rate of ambivalent parent-child relationships or even abusive relationships and a high rate of serious discrimination within the societies in which these children are raised.

Ala54Thr fatty acid-binding protein 2 (FABP2) polymorphism in recurrent depression: associations with fatty acid concentrations and waist circumference

BackgroundFatty acid (FA)-alterations may mediate the mutual association between Major Depressive Disorder (MDD) and cardiovascular disease (CVD). However, etiology of observed FA-alterations in MDD and CVD remains largely unclear. An interesting candidate may be a mutation in the fatty acid–binding protein 2 (FABP2)-gene, because it regulates dietary FA-uptake.

Accuracy of the MacArthur Competence Assessment Tool for Clinical Research (MacCAT-CR) for Measuring Children's Competence to Consent to Clinical Research

gastroenterology, oncology, ophthalmology, and pulmonology from January 1, 2012, through January 1, 2014. Participants were eligible for clinical research studies, including observational studies and randomized clinical trials. Exposures Competence judgments by experts aware of the 4 relevant criteria—understanding, appreciation, reasoning, and choice—were used to establish the reference standard.