Conclusion: There are no specific drugs for PTSD, except for the treatment of irritability and depressive features with SSRI. Atypical neuroleptics have been more recently been introduced as well as mood stabilizers. Other options are specific serotonergic agents such as 5-HT 1A antagonists, NA-blockers, CRF antagonists, GC-receptor antagonists, prazosin and á1-adrenergic blocker with nightmares, use of â-blockers early after trauma exposure are investigated.