N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids. Using a high-throughput screen, chemical proteomics and targeted lipidomics, we report here the discovery and characterization of LEI-401 as a CNS-active N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor.

This study aimed to explore posttraumatic growth (PTG) in displaced Syrians in the UK, using a mixed-methods approach. Fifty-four Syrian adults in the UK who left Syria as result of the war were recruited online to complete the PTG-Inventory. Five participants with high PTG scores were interviewed via Skype to explore their experiences of PTG. Interviews were analyzed using Interpretive Phenomenological Analysis. Results showed that displaced Syrians in the UK experience high levels of PTG.

Background: The impact of armed conflict and displacement on children’s mental health is strongly mediated by compromised parenting stemming from persistently high caregiver stress. Parenting interventions for refugees emphasize the acquisition of parenting knowledge and skills, while overlooking the deleterious effects of chronic stress on parenting.

Suicide and suicidal behaviors represent a leading cause of morbidity and mortality during adolescence. While several lines of evidence suggest that suicidal behaviors are associated with risky decisions and deficient cognitive control in laboratory tasks in adults, comparatively less is known about adolescents. Here, we systematically reviewed the literature on the association between these neurocognitive variables and adolescent suicidal behaviors.

Objective

To conduct a systematic review and meta‐analysis of the existing evidence on the association between age at migration and the risk of psychotic disorders.

Methods

Background

Before the COVID-19 pandemic, coronaviruses caused two noteworthy outbreaks: severe acute respiratory syndrome (SARS), starting in 2002, and Middle East respiratory syndrome (MERS), starting in 2012. We aimed to assess the psychiatric and neuropsychiatric presentations of SARS, MERS, and COVID-19.

Methods

A detailed study shows that young migrants’ risk of developing psychiatric disorders rises stepwise with the number of traumas experienced.

Voor Nederlanders met psychische problemen is de kans vier keer zo groot dat zij daar hulp bij ontvangen dan voor een asielzoeker. Terwijl juist asielzoekers psychisch veel te lijden hebben.

Hoe is de psychische zorg voor asielzoekers eigenlijk geregeld?

Bijna 1 miljoen Duitse vrouwen werden aan het einde van de Tweede Wereldoorlog verkracht.

Hun kinderen lijden nog altijd onder de gevolgen. „Zij werden met een erfschuld geboren.”

Niet welkom zijn. De van oorsprong Duitse Karin wist hoe dat was.

Als kind vluchtte ze met haar moeder en zusje uit het door oorlog getekende Silezië voor de aanstormende Russen.

Tien jaar later kwam ze met haar Hollandse verloofde naar een Nederland dat niet zat te wachten op Duitsers.