Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia

Age-associated memory decline is due to variable combinations of genetic and environmental risk factors. How these risk factors interact to drive disease onset is currently unknown.

Here we begin to elucidate the mechanisms by which post-traumatic stress disorder (PTSD) at a young age contributes to an increased risk to develop dementia at old age.

We show that the actin nucleator Formin 2 (Fmn2) is deregulated in PTSD and in Alzheimer’s disease (AD) patients.

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EHRI Portal Manual

The EHRI Online Portal allows you to explore information about Holocaust-related institutions and their collections across Europe and beyond. It is one of the main achievements of the European Holocaust Research Infrastructure (EHRI) project, and it seeks to overcome one of the hallmark challenges of Holocaust research: the fragmentation and wide geographic dispersal of archival sources documenting the event.

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EHRI Portal

The EHRI portal offers access to information on Holocaust-related archival material held in institutions across Europe and beyond.

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EHRI Portal Introduction

This video gives a short introduction to the what, why and how of the online portal of the European Holocaust Research Infrastructure, in just under 3 minutes. www.ehri-project.eu

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Intensive prolonged exposure treatment for adolescent complex posttraumatic stress disorder : a single-trial design

Background

The current study evaluated the effectiveness and safety of intensive prolonged exposure (PE) targeting adolescent patients with complex posttraumatic stress disorder (PTSD) and comorbid disorders following multiple interpersonal trauma.

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An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene

Posttraumatic stress disorder (PTSD) is a debilitating psychiatric syndrome with complex etiology. Studies aiming to explore genetic susceptibility and environmental triggers of PTSD have been increasing. However, the results are limited and highly heterogeneous. To understand the genetic study status of PTSD and explore more reliable candidates, we obtained 105 PTSD related genetic studies by comprehensively literature searching and filtering 1762 studies. Detailed phenotype and sample information for each study and association results for each genetic marker were extracted.

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Screening for trauma-related symptoms via a smartphone app : The validity of Smart Assessment on your Mobile in referred police officers

To facilitate easily accessible screening for trauma-related symptoms, a web-based application called Smart Assessment on your Mobile (SAM) was developed. In this study, we examined whether SAM was able to accurately identify posttraumatic stress disorder (PTSD) and depression in adults.

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Prevalence of use of erectile dysfunction medication by Dutch military personnel between 2003 and 2012.

Use of ED medication can be seen as a marker for ED. ED is associated with increasing age, exposure to traumatic events and physical injuries in military veterans. The objective of this study was to assess the prevalence of use of ED medication in Dutch military personnel in the period 2003–2012 and to assess its association with age and psychotropic medication use. Data on dispensing of ED medication, age and co-medication with psychotropic medication of all Dutch military personnel between 2003 and 2012 were collected.

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De ggz en psychosociale hulp bij rampen en crises

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An attitude of helplessness : basic counselling in Bukavu, Democratic Republic of Congo

The Democratic Republic of Congo has suffered armed conflict for over 20 years, with the eastern provinces being particularly impacted by destruction and structural violence. The consequences of this ongoing violence are visible on the streets and in the homes of the people, as well as specifically affecting the minds of the country's youth. This personal reflection highlights the work of a psychologist at a vocational training centre in Bukavu.

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