This thesis deals with organizational, cultural and personal factors involved in the execution of biomedical research. More specifically, the prime goal of this thesis is to describe publication culture and to unravel different factors related to biomedical science and scientists that might influence the publication process. I focus on factors related to the scientist him- or herself; perceived publication pressure, burnout symptoms in scientists, self-reported research misbehavior, biases in interpreting scientific information, and personality traits.