Posttraumatic stress disorder (PTSD) is a disabling psychiatric disorder that develops in approximately 10% of people exposed to trauma. As traumatic events are the point of reference for PTSD symptom onset, the first hours to weeks posttrauma provide opportunities for preventive interventions. In this article, we discuss current evidence on pharmacological preventive interventions for PTSD in adults. We conclude that there are no pharmacological preventive interventions that are ready for routine clinical practice.

Studies suggest that sleep supports persistent changes in the neuronal representation of emotional experiences such that they are remembered better and less distressful when recalled than when they were first experienced. It is conceivable that sleep fragmentation by arousals, a key characteristic of insomnia disorder, could hamper the downregulation of distress. In this study, we sought further support for the idea that insomnia disorder may involve a lasting deficiency to downregulate emotional distress.

Stress dysregulation is a transdiagnostic marker of emotional disorders, related to biases in attention toward negative information. We adapted a computerized process-based training targeting these attention mechanisms through mouse-based contingency responses and examined its effects on reappraisal and rumination.

Background: The World Health Organization(WHO) International Classification of Diseases, 11th version (ICD-11), has proposed a new trauma-related diagnosis of complex posttraumatic stress disorder (CPTSD), separate and distinct from posttraumatic stress disorder (PTSD). However, to date, no study has examined CPTSD over time.

Objectives: This prospective study aimed to examine predictors and outcomes of latent classes of PTSD and CPTSD following war captivity.