The long-term course of anxiety disorders : An epidemiological perspective

Anxiety disorders are very common and impose a considerable burden for patients, relatives, and society. There are several anxiety disorders, all of which are known for their often persistent course. Nevertheless, there is a lack of knowledge about its longitudinal course trajectories, which hampers prevention strategies and adjustment of treatments according to prognosis. The aim of this thesis was to get more insight into the longitudinal multi-year naturalistic course of anxiety disorders and to identify the factors that are associated with this course.

 

Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes

Study Objectives: Sleep problems are common, serving as both a predictor and symptom of posttraumatic stress disorder (PTSD), with these bidirectional relationships well established in the literature. While both sleep phenotypes and PTSD are moderately heritable, there has been a paucity of investigation into potential genetic overlap between sleep and PTSD.

Predicting future risk of PTSD

Data routinely collected in the emergency department after trauma have the potential to predict those at risk of later PTSD, which shows promise for computational psychiatry.

Clustering of suicides in children and adolescents

Suicide is one of the major causes of death in young people, in whom suicide can occur in clusters. In this Review, we have investigated definitions and epidemiology of such clusters, the factors associated with them, mechanisms by which they occur, and means of intervening and preventing them. Clustering of suicidal behaviour is more common in young people (<25 years) than adults. Suicide clusters can occur as a greater number of episodes than expected at a specific location, including in institutions (eg, schools, universities, psychiatric units, and youth offender units). 

Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR

Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed controls. Here, we describe the results of the largest DNA methylation meta-analysis of PTSD to date. Ten cohorts, military and civilian, contribute blood-derived DNA methylation data from 1,896 PTSD cases and trauma-exposed controls. Four CpG sites within the arylhydrocarbon receptor repressor (AHRR) associate with PTSD after adjustment for multiple comparisons, with lower DNA methylation in PTSD cases relative to controls.

The impact of brief intensive trauma-focused treatment for PTSD on symptoms of borderline personality disorder

Background: It is generally recommended to exercise caution in applying trauma-focused treatment to individuals with posttraumatic stress disorder (PTSD) and comorbid borderline personality disorder (BPD).

 

Objective: To investigate the effects of a brief, intensive, direct trauma-focused treatment programme for individuals with PTSD on BPD symptom severity.

 

The role of prenatal stress as a pathway to personality disorder : longitudinal birth cohort study

Background

Many studies have reported associations between prenatal stress and the development of psychotic, anxiety and depressive disorders; however, to date no studies have investigated potential associations with personality disorders.

Aims

The course of (comorbid) trauma-related, dissociative and personality disorders : two year follow up of the Friesland study cohort

Background: There is substantial comorbidity between trauma-related disorders (TRDs), dissociative disorders (DDs) and personality disorders (PDs), especially in patients who report childhood trauma and emotional neglect. However, little is known about the course of these comorbid disorders, despite the fact that this could be of great clinical importance in guiding treatment.

 

Understanding Moral Injury In Police Online Child Sex Crime Investigators

What are the contributing factors to moral injury in child exploitation investigators, and how can these factors be mitigated?
Throughout their careers, police officers are exposed to an estimated 900 traumatic events, which, coupled with organisational stressors, contribute to mental ill-health and psychological trauma.

Repeated exposure to work-related traumatic incidents, impedes the ability for many police officers to cope, with the concurrent risk of developing psychopathology and moral injury.

Barriers and Facilitators to Help‐Seeking for Individuals With Posttraumatic Stress Disorder : A Systematic Review

Posttraumatic stress disorder (PTSD) brings with it diagnostic symptoms that can be debilitating and persist for years. Left untreated, PTSD can have far‐reaching and damaging consequences for the individual, families, communities, and society at large. Although early detection and intervention are recognized as key to the effective treatment of PTSD, many individuals who suffer from PTSD do not seek essential health services. The aim of the present study was to identify the barriers and facilitators to help‐seeking for individuals with PTSD, based on existing literature.

 

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