The one-carbon-cycle and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in recurrent Major Depressive Disorder, influence of antidepressant use and depressive state?

AbstractBackgroundAn important biological factor suggested in the pathophysiology of (recurrent) Major Depressive Disorder (MDD) concerns a polymorphism in a gene encoding for the MTHFR-enzyme of the one-carbon (1-C)-metabolism.

The heterogeneity of long-term grief reactions

Background Individuals experience the loss of a spouse in varied ways. There is growing recognition of major depressive disorder and complicated grief as distinct post-bereavement disorders. However, most studies focusing on these different courses of functioning have not examined pre-loss functioning. Methods We used data from a prospective population based study to examine depression and grief among conjugally bereaved older adults.

The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD. Evidence from a randomized controlled trial

Posttraumatic stress disorder (PTSD) is associated with a reduced ratio of na+»ve cytotoxic T lymphocytes, an increased ratio of memory cytotoxic T lymphocytes, and a reduced proportion of FoxP3+ regulatory T lymphocytes. This study investigated whether these immunological alterations are reversible through an evidence-based psychotherapeutic treatment. Therefore, 34 individuals with PTSD were randomly assigned to either a treatment condition of 12 sessions Narrative Exposure Therapy (NET) or a waitlist control (WLC) group.

The efficacy of psychosocial interventios for adults in contexts of ongoing man-made violence - A systematic review

ABSTRACTCompared to psychosocial programs implemented in post-conflict settings those executed in areas of ongoing conflicts may have different effects. Their evidence of efficacy has never been systematically reviewed. We searched PubMed, PsychInfo and the Dutch Tropical Institute Literature Portal from inception to31 January 2013 to identify studies on community-oriented psychosocial and psychiatric/clinical services for adults during ongoing manmade conflict or its direct aftermath. Of 6358 articles screened, 16 met our inclusion criteria.

The Body keeps the score : brain, mind, and body in the healing of trauma

Van der Kolk transforms the understanding of traumatic stress, revealing how it literally rearranges the brain’s wiring—specifically areas dedicated to pleasure, engagement, control, and trust. He shows how these areas can be reactivated through innovative treatments including neurofeedback, mindfulness techniques, play, yoga, and other therapies.

The Clinical Sequelae of Dysfunctional Defense Responses: Dissociative Amnesia, Pain and Somatization, Emotional Motor Memory, and Interoceptive Loops

To maximize the possibility of survival in a situation of extreme danger, the defense responses have an immediacy that confers precedence of the midbrain over the cortex (Mobbs et al., 2009). This is especially important in the child's brain, which develops from ...

Systematic review of the prevalence and characteristics of battle casualties from NATO coalition forces in Iraq and Afghanistan

BACKGROUND: The North Atlantic Treaty Organization (NATO) coalition forces remain heavily committed on combat operations overseas. Understanding the prevalence and characteristics of battlefield injury of coalition partners is vital to combat casualty care performance improvement. The aim of this systematic review was to evaluate the prevalence and characteristics of battle casualties from NATO coalition partners in Iraq and Afghanistan.

'Strength at Home' Intervention to Prevent Conflict and Violence in Military Couples: Pilot Findings

In this article, we report on a pilot study of Strength at Home-Couples (SAH-C), a 10-session cognitive-behavioral couples-based group intervention designed to prevent intimate partner violence (IPV) in military couples. The primary purposes of this pilot study were to determine feasibility of recruiting, retaining, and assessing SAH-C participants in addition to those participating in a comparison Supportive Therapy (ST) group-based couples intervention.

Sleep Disturbances Predict Later Trauma-Related Distress: Cross-Panel Investigation Amidst Violent Turmoil

Objective: Sleep disturbances, including trouble falling and remaining asleep and recurrent nightmares, are symptoms of posttraumatic stress. A growing body of literature indicates that sleep disturbance may also convey vulnerability for the continuation of other symptoms of posttraumatic stress, including fear, anxiety, and heightened arousal. However, longitudinal research, which could help understand how these relationships unfold over time, has been limited.

Sleep structure and emotional memory processing in police officers and combat veterans with PTSD

Disturbed sleep is one of the key symptoms of posttraumatic stress disorder (PTSD) and may contribute to the genesis and maintenance of PTSD. Our previously published study*, executed in healthy subjects, suggests that adaptive changes occur in sleep architecture, after emotional experiences, that benefit emotional housekeeping and the attenuation of emotional responses to negative emotional experiences. Little is known, however, about the relation between sleep and emotional memory processing in PTSD.

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