Repeated intranasal oxytocin administration as early preventive intervention for PTSD : A randomized controlled trial.

As posttraumatic stress disorder (PTSD) develops in approximately 10% of trauma-exposed individuals, there is an urgent need for effective preventive interventions for PTSD [1]. Oxytocin administration was previously found to beneficially influence neurobiological and socio-emotional factors associated with increased PTSD risk [e.g. 2, 3]. Therefore, we hypothesized that intranasal oxytocin administration early post-trauma in trauma-exposed individuals could prevent PTSD development .

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Memory consolidation reconfigures neural pathways involved in the suppression of emotional memories

The ability to suppress unwanted emotional memories is crucial for human mental health. Through consolidation over time, emotional memories often become resistant to change. However, how consolidation impacts the effectiveness of emotional memory suppression is still unknown. Using event-related fMRI while concurrently recording skin conductance, we investigated the neurobiological processes underlying the suppression of aversive memories before and after overnight consolidation.

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Is there a vulnerability paradox in PTSD? : Pitfalls in cross-national comparisons of epidemiological data

Dückers et al analyse the relationship between prevalence estimates of trauma exposure and post-traumatic stress disorder (PTSD) in published data-sets from 24 countries, and between PTSD and vulnerability (based on a country vulnerability index developed in the 2013 World Risk report). The findings are substantially counterintuitive; countries with low vulnerability have higher life-time rates of PTSD, meaning that countries with low vulnerability and high trauma exposure have the highest rates of lifetime PTSD.

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PTSD symptom trajectories in disaster volunteers : The role of self-efficacy, social acknowledgement, and tasks carried out

Millions of volunteers respond after disasters, with a 24% to 46% risk of developing posttraumatic stress disorder (PTSD). It is unclear which symptom trajectories develop and how they differ between core (volunteering before the disaster) and noncore volunteers (joining after the disaster) and which factors predict trajectories. Symptoms of PTSD were assessed at 6-, 12-, and 18-months postearthquake in 449 volunteers in Indonesia.

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Trauma occurs in social contexts

Vilnius, Lithuania's capital, was the beautiful location of the 14th Conference of the European Society of Traumatic Stress studies (ESTSS) from June 10 to 13, 2015. The main theme of this two-yearly conference was “Trauma in changing societies: social contexts and clinical practice.” The topic of the conference is timely, unfortunately. The current crisis in Syria changed (and is still changing) societies, especially in the Middle East.

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Intranasal oxytocin enhances neural processing of monetary reward and loss in post-traumatic stress disorder and traumatized controls

Abstract
Background
Anhedonia is a significant clinical problem in post-traumatic stress disorder (PTSD). PTSD patients show reduced motivational approach behavior, which may underlie anhedonic symptoms. Oxytocin administration is known to increase reward sensitivity and approach behavior. We therefore investigated whether oxytocin administration affected neural responses during motivational processing in PTSD patients and trauma-exposed controls.
Methods

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Cognitive behavioural therapy for psychopathology in relatives of missing persons : study protocol for a pilot randomised controlled trial

Abstract
Background: It is hypothesized that the grieving process of relatives of missing persons is complicated by having
to deal with uncertainty about the fate of their loved one. We developed a cognitive behavioural therapy (CBT)
with mindfulness that focuses on dealing with this uncertainty. In this article, we elucidate the rationale of a pilot
randomised controlled trial (RCT) for testing the feasibility and potential effectiveness of this CBT for reducing

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Intranasal Oxytocin Affects Amygdala Functional Connectivity after Trauma Script-Driven Imagery in Distressed Recently Trauma-Exposed Individuals.

Approximately 10% of trauma-exposed individuals go on to develop post-traumatic stress disorder (PTSD). Neural emotion regulation may be etiologically involved in PTSD development. Oxytocin administration early post-trauma may be a promising avenue for PTSD prevention, as intranasal oxytocin has previously been found to affect emotion regulation networks in healthy individuals and psychiatric patients.

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Borderlands of mental health : Explorations in medical anthropology, psychiatric epidemiology and health systems research in Afghanistan and Burundi

Many areas of the globe today face continuous armed conflict, with more and more populations caught in the crossfire. This has been true in both Afghanistan and Burundi where populations have to cope with the psychological and social effects of ongoing collective violence. While living and working in these countries, the author conducted research on the impact of these complex humanitarian emergencies on mental health and psychosocial wellbeing, and on ways to miti gate these impacts.
His findings as published in this PhD thesis are based on the following questions:

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