Attenuating human fear memory retention with minocycline : a randomized placebo-controlled trial

Pavlovian fear conditioning is widely used as a pre-clinical model to investigate methods for prevention and treatment of anxiety and stress-related disorders. In this model, fear memory consolidation is thought to require synaptic remodeling, which is induced by signaling cascades involving matrix metalloproteinase 9 (MMP-9). Here we investigated the effect of the tetracycline antibiotic minocycline, an inhibitor of MMP-9, on fear memory retention.

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Recurrence of post-traumatic stress disorder : systematic review of definitions, prevalence and predictors

Background

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The Impact of Ketamine for Treatment of Post-Traumatic Stress Disorder : A Systematic Review With Meta-Analyses

Background:
Ketamine has been used in anesthesia, pain management, and major depressive disorder. It has recently been studied in patients with post-traumatic stress disorder (PTSD).
 

Objective:
To determine the impact of ketamine on PTSD symptomatology and depression scores.
 

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A systematic review of the incidence of medical serious adverse events in sub-anesthetic ketamine treatment of psychiatric disorders

Background
Limited published data exists that collates serious adverse outcomes involving ketamine as a psychiatric intervention. This systematic review assesses the reported incidence of medical serious adverse events (MSAEs), including but not limited to cardiovascular events, in patients receiving sub-anesthetic doses of ketamine for psychiatric disorders to guide practitioners during treatment planning, risk-benefit analyses, and the informed consent process.

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Treatment of Posttraumatic Stress Disorder : A State-of-the-art Review

This narrative state-of-the-art review paper describes the progress in the understanding and treatment of Posttraumatic Stress Disorder (PTSD). Over the last four decades, the scientific landscape has matured, with many interdisciplinary contributions to understanding its diagnosis, etiology, and epidemiology. Advances in genetics, neurobiology, stress pathophysiology, and brain imaging have made it apparent that chronic PTSD is a systemic disorder with high allostatic load.

 

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Perspectives on dying in severe and enduring eating disorders (SEEDs) : A qualitative study among Dutch mental healthcare providers

Dying of severe and enduring eating disorders (SEEDs) was studied using semi-structured interviews (n=7) and a follow-up videoconferencing focus group (n=3) with Dutch mental healthcare providers. We identified three main themes: the uncertainties of dying from SEEDs, dilemmas in defining treatment resistance and palliative care, and suicidal ideation and intent.

 

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A randomized controlled trial of Deep Brain Reorienting : a neuroscientifically guided treatment for post-traumatic stress disorder

Background:

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Efficacy and Safety of Four Psychedelic-Assisted Therapies for Adults with Symptoms of Depression, Anxiety, and Posttraumatic Stress Disorder : A Systematic Review and Meta-Analysis

There has been a resurgence in psychedelic research for managing psychiatric conditions in recent years.

 

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Treatment of multiple traumatized adolescents by enhancing regulation skills and reducing trauma related symptoms : rationale, study design, and methods of randomized controlled trial (the Mars-study)

Background

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Telepsychiatry versus face-to-face treatment : systematic review and meta-analysis of randomised controlled trials

Background
The COVID-19 pandemic has transformed healthcare significantly and telepsychiatry is now the primary means of treatment in some countries.

Aims

To compare the efficacy of telepsychiatry and face-to-face treatment.

Method

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