A retrospective study of ketamine administration and the development of acute or post-traumatic stress disorder in 274 war-wounded soldiers

The objective of this study was to explore whether ketamine prevents or exacerbates acute or post-traumatic stress disorders in military trauma patients. We conducted a retrospective study of a database from the French Military Health Service, including all soldiers surviving a war injury in Afghanistan (2010–2012). The diagnosis of post-traumatic stress disorder was made by a psychiatrist and patients were analysed according to the presence or absence of this condition.

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Preventing PTSD with oxytocin : effects of oxytocin administration on fear neurocircuitry and PTSD symptom development in recently trauma-exposed individuals

ABSTRACT

Background: Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder which

develops in approximately 10% of trauma-exposed individuals. Currently, there are few early

preventive interventions available for PTSD. Intranasal oxytocin administration early posttrauma

may prevent PTSD symptom development, as oxytocin administration was previously

found to beneficially impact neurobiological (e.g. amygdala reactivity) and socio-emotional

PTSD vulnerability factors.

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Intranasal oxytocin : miracle cure after trauma?

Background: In popular media and on Internet, the neuropeptide oxytocin is often advertised as a miracle drug that cures all

types of disorders, reduces stress, saves marriages, all conveniently with a nasal spray. Here we will present the effects of intranasal

oxytocin on brain function in recently traumatized individuals and patients with posttraumatic stress disorder (PTSD) and

discuss clinical implications and further research. PTSD is characterized by exaggerated fear responses to threat and traumarelated

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Plasma lipoproteins in posttraumatic stress disorder patients compared to healthy controls and their associations with the HPA- and HPT-axis

Abstract

Background

Based on studies among primarily male veteran subjects, lipoproteins are thought to mediate the association of posttraumatic stress disorder (PTSD) with cardiovascular disease (CVD). However, recent civilian studies with female samples or samples with both sexes represented provide little evidence for this association. Gender, diet and sex-specific effects of stress hormones on lipoproteins may explain this dissociation in findings.

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Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder : systematic review and meta-analysis of relapse prevention trials

Objectives To examine the risk of relapse and time to relapse after discontinuation of antidepressants in patients with anxiety disorder who responded to antidepressants, and to explore whether relapse risk is related to type of anxiety disorder, type of antidepressant, mode of discontinuation, duration of treatment and follow-up, comorbidity, and allowance of psychotherapy.

 

Design Systematic review and meta-analyses of relapse prevention trials.

 

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Scope, Scale, and Dose of the World’s Largest School-Based Mental Health Programs

Untreated mental health problems are among the most disabling, persistent, and costly health conditions.

Because they often begin in childhood and continue into adulthood, there has been growing interest in preventive mental health programs for children.

In recent years, several such programs have been implemented at regional, state, or national scale, and although many experimental studies have documented positive outcomes of individual programs, this article represents the first attempt to systematically compare the largest programs in terms of scope, scale, and dose.

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Setting the stage for recovery. Improving veteran PTSD treatment effectiveness using statistical prediction

Over half a million Dutch veterans participated in almost a hundred war and peace keeping missions since 1940. During past deployments, veterans promoted peace and stability in conflict situations, endeavoured to win the hearts and minds of local communities and improved the lives of those affected in warzone circumstances. These men and women operated under harsh conditions that placed them at the vanguard of human violence and tragedy.

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Intensive prolonged exposure treatment for adolescent complex posttraumatic stress disorder : a single-trial design

Background

The current study evaluated the effectiveness and safety of intensive prolonged exposure (PE) targeting adolescent patients with complex posttraumatic stress disorder (PTSD) and comorbid disorders following multiple interpersonal trauma.

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Dance/Movement therapy and resilience building with female asylum seekers and refugees : a phenomenological practice based research

This phenomenological study aims to better understand the applicability of Dance/Movement therapy for traumatised women asylum seekers and refugees. It explores if and how bodily engagement could support an existing resilience based treatment model employed at a centre for transcultural psychiatry in the Netherlands. The sessions focused on moving the body and included the use of music, props, mirroring techniques, body awareness and movement exploration exercises. Participation in the sessions was associated with self-reported alleviation of stress and addressed vulnerabilities.

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Oxytocin receptor gene polymorphisms, attachment, and PTSD : Results from the National Health and Resilience in Veterans Study

The human oxytocin system is implicated in social behavior and stress recovery. Polymorphisms in the oxytocin receptor gene (OXTR) may interact with attachment style to predict stress-related psychopathology like posttraumatic stress disorder (PTSD). The objective of this study was to examine independent and interactive effects of the OXTR single nucleotide polymorphism (SNP) rs53576, which has been associated with stress reactivity, support-seeking, and PTSD in prior studies, and attachment style on risk for PTSD in a nationally representative sample of 2163 European-American (EA) U.S.

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