Discontinuation Rates of Antidepressant Use by Dutch Soldiers

Introduction: Soldiers have a higher risk for developing psychiatric disorders that require treatment; often with antidepressants. However, antidepressants as well as the psychiatric disorder, may influence military readiness in several ways. In the general population, early discontinuation of antidepressant treatment is often seen. It is yet unknown whether this occurs to a similar extent in soldiers. The objective of this study was to evaluate discontinuation of antidepressant use by Dutch soldiers in the first 12 months after start and determinants thereof.

 

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Effectiveness of trauma-focused treatment for adolescents with major depressive disorder

Background: Major Depressive Disorder (MDD) in adolescence has a high prevalence and risk of disability, but current treatments show limited effectiveness and high drop-out and relapse rates. Although the role of distressing experiences that relate to the development and maintenance of MDD has been recognized for decades, the efficacy of a trauma-focused treatment approach for MDD has hardly been studied.

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Circulating Serum MicroRNAs as Potential Diagnostic Biomarkers of Posttraumatic Stress Disorder : A Pilot Study

Posttraumatic stress disorder (PTSD) is a psychiatric disorder that can develop upon exposure to a traumatic event. While most people are able to recover promptly, others are at increased risk of developing PTSD. However, the exact underlying biological mechanisms of differential susceptibility are unknown. Identifying biomarkers of PTSD could assist in its diagnosis and facilitate treatment planning. Here, we identified serum microRNAs (miRNAs) of subjects that underwent a traumatic event and aimed to assess their potential to serve as diagnostic biomarkers of PTSD.

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Post-traumatic stress disorder : a state-of-the-art review of evidence and challenges

Post-traumatic stress disorder (PTSD) is arguably the most common psychiatric disorder to arise after exposure to a traumatic event. Since its formal introduction in the DSM-III in 1980, knowledge has grown significantly regarding its causes, maintaining mechanisms and treatments. Despite this increased understanding, however, the actual definition of the disorder remains controversial.

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Internet-delivered cognitive behavioural therapy for post-traumatic stress disorder : systematic review and meta-analysis

Objective: To determine whether Internet-delivered cognitive behavioural therapy (i-CBT) is an effective treatment for those who meet diagnostic criteria for post-traumatic stress disorder (PTSD). 
Method: A systematic review was undertaken according to Cochrane Collaboration Guidelines. The primary outcome measures were reduction in PTSD symptoms and drop-out. Categorical outcomes were meta-analysed as risk ratios (RRs) and continuous outcomes as mean differences (MDs) or standardised mean differences (SMDs).

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Stronger Than My Ghosts : Narrative Exposure Therapy and Cognitive Recovery in Later Life

Background: To explore cognitive recovery during and after Narrative Exposure Therapy from the patient’s perspective, autobiographical material and interview responses were qualitatively
analyzed.

 

Method: Using a framework of cognitive development, patient-reported outcomes from four senior Dutch citizens (57–81 years of age) were examined. All participants reported multiple traumatic experiences, including adverse childhood experiences.

 

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Randomised controlled trial comparing narrative exposure therapy with present-centred therapy for older patients with post-traumatic stress disorder

Background: Evidence-based treatment and age-specific services are required to address the needs of trauma-affected older populations. Narrative exposure therapy (NET) may present an appropriate treatment approach for this population since it provides prolonged exposure in a lifespan perspective. As yet, however, no trial on this intervention has been conducted with older adults from Western Europe.

Aims: Examining the efficacy of NET in a sample of older adults.

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Barriers to mental health services at public health centers : Providers’ perspectives

Background and purpose: The disparity between the increasing prevalence of mental health (MH) illness and the availability of treatment in Indonesia remains high, despite the campaign to provide MH services at public health centers (PHCs) initiated by the government in 2014. This study explored barriers to MH service provision at PHCs in Denpasar, Bali, Indonesia in order to identify priorities for service improvement. 

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Eating disorders and posttraumatic stress disorder

Purpose of review: Childhood maltreatment is associated with all types of eating disorders. We provide a systematic review of the recent literature on comorbid posttraumatic stress disorder (PTSD) in patients with eating disorders, and focus on prevalence, relationship with symptom severity, operating mechanisms and treatment.

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MDMA-assisted psychotherapy for posttraumatic stress disorder : A promising novel approach to treatment

Posttraumatic stress disorder (PTSD) treatment guidelines have unequivocally designated psychotherapy as a first-line treatment, despite well-documented neurobiological alterations in this disorder [1]. Even with psychotherapy, PTSD often remains chronic and severe. There is urgency to discover novel compounds and new treatment strategies for PTSD.

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