What are the likely mental and related physical health consequences of prolonged exposure to common stressors to detainees at Guantanamo Bay, Cuba? Significant distress leads to high rates of psychiatric disorders, medical problems, and functional impairments. The consequences are severe, physically and psychologically, affecting the individual, his or her family, and the culture at large. Damaging conditions endured by detainees are multiple and severe and are reviewed here in detail.